H4CBD is one of the newest cannabinoids on the market, so it's quite possible you haven't heard of it. You will only find a few brands if any on the market that deal with the production of products with this cannabinoid.
What is H4CBD and how is it produced?
H4CBD is a cannabinoid that was created by synthetically modifying CBD. This cannabinoid is a hexahydroderivative of CBD, which means that four hydrogen atoms have been added to the CBD molecule. This manufacturing process improves the bioavailability of H4CBD, meaning the body can more easily absorb and use this cannabinoid.
How is hydrogenated H4CBD produced? Simply put, we can liken the production process to the way margarine is made from vegetable oil.
H4CBD or THD / TETRAHYDROCANNABIDIOL is a derivative of CBD that is produced in the laboratory or semi-synthetically. Also known as hydrogenated CBD, this cannabinoid was created as an alternative form of conventional CBD. Scientists have been researching and developing semi-synthetic and synthetic cannabinoids since the mid-20th century.
H4CBD is not found in nature. This means that there are no strains of cannabis containing H4CBD. Since it is not possible to extract natural H4CBD, this cannabinoid can only be produced by hydrogenation.
How does H4CBD work?
H4CBD is still “in its infancy”, i.e. it remains a relatively unexplored cannabinoid, but the few information about it suggests that it has an affinity for CB1 neuroreceptors.
H4CBD is actually a modified version of CBD, but with the difference that it affects the mind. The effects are similar to HHC, but H4CBD does not contain a double bond. H4CBD is made up of two diastereomers, R and S, with the R diastereomer having noticeably stronger effects than the S diastereomer.
H4CBD-TETRAHYDROCANNABIDIOL is not intoxicating and users have described their experience by comparing the effects to CBD with “baby kick” effect of THC. H4CBD produces a noticeable uplifting and relaxing effect as a “CBD you can feel” to the average CBD users.
Currently, there is no indication that hydrogenated CBD is dangerous. However, we still think it is important to wait for more studies and clinical trials before making any concrete conclusions. As always, we would advise you – too much of everything is harmful, and this is doubly true for products with cannabinoids.
Cannabinoids are also known for their ability to calm stress, anxiety and promote relaxation and calmness. CBD is often used for this purpose of relaxation. Its counterpart, H4CBD, has the same calming effects, but to a tenfold extent. This will at least give you an idea of the level of relaxation that can be achieved with H4CBD.
Is H4CBD the same as CBD and how does it compare with HHC?
The answer is, “No, it’s not.” Although the two cannabinoids share some properties, they are different molecules. For example, they have completely different effects, and the fundamental differences lie in their chemical structures and methods of production.
H4CBD and HHC are different substances, although their origin is similar. HHC is the hydrogenated version of THC, whereas H4CBD is the hydrogenated CBD version. Each is based on different basic molecules. This difference also results in different effects on the body.
H4CBD vs CBD. What they have in common?
Both CBD and H4CBD come from hemp. CBD is a direct derivative of hemp, whereas H4CBD Tetrahydrocannabidiol undergoes a transformation process, including hydrogenation, to reach its final form.
Because of this, H4CBD is considered a synthetic cannabinoid, even though it is only synthetic as margarine. Technically, it is also possible to synthesise CBD. However, there is no reason to do so, as this cannabinoid is abundant in cannabis.
H4CBD has been structurally modified to take on a different form than CBD. This is a chemical process that inserts hydrogen atoms into the selected molecule. Four additional hydrogen atoms , are added to the molecule, altering its natural properties.
If we look at a single study from 2006, we find that the study says that hydrogenated CBD have an extremely high affinity for the brain’s CB1 neuro-receptors. It is this finding that has expanded speculation that H4CBD may have effects up to a hundred times greater than CBD – at least in some ways.
A review of research from 2017 confirmed this assumption, but no new studies on the bioactive properties of H4CBD have been conducted.
H4CBD could provide users with something in the range of three times the potency of CBD. H4CBD is reported to offer 100 times the potency of regular CBD. However, we’ve already learned that even if this is the case, it only applies to the potency of CBD on CB1 receptors. And this efficacy was initially negligible for CBD.
H4CBD at CB1 receptors requires further investigation to draw any conclusions related to potential increased activity.
So calling out to the world that H4CBD is “100 times more potent” than CBD in all areas is a rather exaggerated claim.
Legality of H4CBD?
The legality of cannabinoids – both synthetic and natural – is currently the subject of much controversy. In general, cannabinoids that are not delta-9 tetrahydrocannabinol are completely legal under the law.
In the United Kingdom, two key pieces of legislation govern the legality of substances like cannabinoids: the Misuse of Drugs Act 1971 and the Psychoactive Substances Act 2016.
The Misuse of Drugs Act 1971 classifies substances into three categories, namely Class A, B, and C, based on their potential harm and misuse. Most cannabinoids, including THC, fall under Class B drugs, making them controlled substances.
On the other hand, the Psychoactive Substances Act 2016 was designed to combat the issue of ‘legal highs’, substances that produce similar effects to illegal drugs but were not covered by the Misuse of Drugs Act. It broadly prohibits the production, supply, and importation of any substance capable of producing a psychoactive effect.
However, H4CBD finds itself in a unique position within the scope of these laws due to its non-psychoactive nature. It is not affected by the Misuse of Drugs Act, nor is it considered a ‘legal high’ under the Psychoactive Substances Act. This means that H4-CBD falls outside the remit of both these laws and is therefore legal in the UK.
While H4CBD is currently legal in the UK, it’s important to remember that the cannabinoid industry is under constant scrutiny and regulation changes can occur. Check in regularly as we provide you with the latest news regarding cannabis laws.
What is the best form to consume H4CBD?
Users generally prefer H4CBD vapes, cartridges and gummies. Over time, capsules, tablets, and even topical H4CBD preparations can also be expected to come to the fore. Whatever the product type, H4CBD products should contain simple ingredients and be accompanied by thorough lab reports.
H4CBD can be seen as a finely-tuned alternative with higher potency, whereas CBD offers a natural variant with lower potency. As modern cannabinoid medicine continues to evolve, both CBD and H4CBD will undoubtedly play a key role.
CBD is very popular and widely used, so it will still dominate the market as one of the main options. However, if H4CBD does indeed abound with specific benefits over CBD, it may earn its reputation in the market and find customers looking for the specific qualities that H4CBD provides.